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More From This Issue. A sample size of 55 per group was estimated to be necessary to detect a clinically significant 6-point between-group difference in the Pain Disability Index PDI. Because of scheduling complexities, patients were randomly assigned to groups at the eligibility visit, visit 0, although the study did not begin until visit 1. The patients with higher PDI scores dropped out because of unwillingness to make multiple visits; the patient with 0 PDI scores could not be contacted. Craniosacral therapy is particularly useful in the treatment of mental stress, neck and back pain, migraines, TMJ Syndrome, and for chronic pain conditions such as fibromyalgia.
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