edema
The pathogenesis of edema in various disease states ranges from the straightforward to the exceedingly complex. Although their absolute values vary considerably at different sites in the body, the interplay among them at a given site always predisposes to net accumulation of interstitial fluid. Abrupt evolution of edema over one to a few days suggests that the underlying cause is deep venous occlusion or cellulitis, especially if the edema is accompanied by pain. At the same time, right atrial hypertension prevents any compensatory increase in lymphatic return. Clinical Significance Edematous extremities can be painful.
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