ibrahim önal kimdir / Поиск | База данных ВОЗ по исследованиям в области COVID

Ibrahim Önal Kimdir

ibrahim önal kimdir

ID: covidwho


Реферат

Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID severity and outcome were previously correlated with Notch4 expression on regulatory T (Treg) cells, here we show that the Treg cells in MIS-C are destabilized in association with increased Notch1 expression. Genetic analysis revealed that MIS-C patients were enriched in rare deleterious variant impacting inflammation and autoimmunity pathways, including dominant negative mutations in the Notch1 regulators NUMB and NUMBL . Notch1 signaling in Treg cells induced CD22, leading to their destabilization in an mTORC1 dependent manner and to the promotion of systemic inflammation. These results establish a Notch1-CD22 signaling axis that disrupts Treg cell function in MIS-C and point to distinct immune checkpoints controlled by individual Treg cell Notch receptors that shape the inflammatory outcome in SARS-CoV-2 infection.

9.

Comparisons of Clinical Features and Outcomes of COVID between Patients with Pediatric Onset Inflammatory Rheumatic Diseases and Healthy Children.

Haslak, Fatih; Varol, Sevki Erdem; Gunalp, Aybuke; Kaynar, Ozge; Yildiz, Mehmet; Adrovic, Amra; Sahin, Sezgin; Kes, Gulsen; Ayzit-Kilinc, Ayse; Akdeniz, Beste; Onal, Pinar; Apaydin, Gozde; Aygun, Deniz; Arslan, Huseyin; Kilic-Baskan, Azer; Hepkaya, Evrim; Meral, Ozge; Barut, Kenan; Cokugras, Haluk Cezmi; Kasapcopur, Ozgur.

J Clin Med ; 11(8) Apr

Статья в английский ID: covidwho


Реферат

BACKGROUND: The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population. METHODS: This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, , to May 31, , children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific antibodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of contact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded. RESULTS: A total of cases were included. While (%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, % were male and % had chronic illnesses. The median age was years (IQR: ) and (%) patients were aged

7.

The ISPAT project: Implementation of a standardized training program for caregivers of children with tracheostomy.

Yilmaz Yegit, Cansu; Kilinc, Ayse Ayzit; Can Oksay, Sinem; Unal, Fusun; Yazan, Hakan; Köstereli, Ebru; Gulieva, Aynur; Arslan, Hüseyin; Uzuner, Selçuk; Onay, Zeynep Reyhan; Kilic Baskan, Azer; Collak, Abdulhamit; Atag, Emine; Ergenekon, Almala Pinar; Bas Ikizoglu, Nilay; Ay, Pinar; Oktem, Sedat; Gokdemir, Yasemin; Girit, Saniye; Cakir, Erkan; Uyan, Zeynep Seda; Cokugras, Haluk; Karadag, Bulent; Karakoc, Fazilet; Erdem Eralp, Ela.

Pediatr Pulmonol ; 57(1): ,

Статья в английский MEDLINE

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