Penis Santimleri

INTRODUCTION

Carcinoma of the penis typically presents as a painless lump or ulcer on the penis. The vast majority of cases are epithelial squamous cell carcinoma (SCC).

The epidemiology, risk factors, and pathology of carcinoma of the penis are reviewed here.

The clinical presentation, diagnosis, staging, and treatment of penile cancer are covered separately:

●(See "Carcinoma of the penis: Clinical presentation, diagnosis, and staging".)

●(See "Carcinoma of the penis: Surgical and medical treatment".)

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This generalized information is a limited summary of diagnosis, treatment, and/or medication information. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patient's specific and unique circumstances. Patients must speak with a health care provider for complete information about their health, medical questions, and treatment options, including any risks or benefits regarding use of medications. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. UpToDate, Inc. and its affiliates disclaim any warranty or liability relating to this information or the use thereof. The use of this information is governed by the Terms of Use, available at seafoodplus.info © UpToDate, Inc. and its affiliates and/or licensors. All rights reserved.

REFERENCES

1. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, CA Cancer J Clin ;
2. Ornellas AA. Management of penile cancer. J Surg Oncol ;
3. Hernandez BY, Barnholtz-Sloan J, German RR, et al. Burden of invasive squamous cell carcinoma of the penis in the United States, Cancer ;
4. Hegarty PK, Kayes O, Freeman A, et al. A prospective study of cases of penile cancer managed according to European Association of Urology guidelines. BJU Int ;
5. Favorito LA, Nardi AC, Ronalsa M, et al. Epidemiologic study on penile cancer in Brazil. Int Braz J Urol ;
6. Rippentrop JM, Joslyn SA, Konety BR. Squamous cell carcinoma of the penis: evaluation of data from the surveillance, epidemiology, and end results program. Cancer ;
7. Daling JR, Madeleine MM, Johnson LG, et al. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer ;
8. Maden C, Sherman KJ, Beckmann AM, et al. History of circumcision, medical conditions, and sexual activity and risk of penile cancer. J Natl Cancer Inst ;
9. Zequi Sde C, Guimarães GC, da Fonseca FP, et al. Sex with animals (SWA): behavioral characteristics and possible association with penile cancer. A multicenter study. J Sex Med ;
10. Barnes KT, McDowell BD, Button A, et al. Obesity is associated with increased risk of invasive penile cancer. BMC Urol ;
11. Bezerra AL, Lopes A, Santiago GH, et al. Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. Cancer ;
12. Lont AP, Kroon BK, Horenblas S, et al. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival. Int J Cancer ;
13. Miralles-Guri C, Bruni L, Cubilla AL, et al. Human papillomavirus prevalence and type distribution in penile carcinoma. J Clin Pathol ;
14. Centers for Disease Control and Prevention (CDC). Human papillomavirus-associated cancers - United States, MMWR Morb Mortal Wkly Rep ;
15. Alemany L, Cubilla A, Halec G, et al. Role of Human Papillomavirus in Penile Carcinomas Worldwide. Eur Urol ;
16. Olesen TB, Sand FL, Rasmussen CL, et al. Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol ;
17. Afonso LA, Cordeiro TI, Carestiato FN, et al. High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis. J Urol ;
18. Giuliano AR, Lazcano-Ponce E, Villa LL, et al. The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiol Biomarkers Prev ;
19. Djajadiningrat RS, Jordanova ES, Kroon BK, et al. Human papillomavirus prevalence in invasive penile cancer and association with clinical outcome. J Urol ;
20. Gunia S, Erbersdobler A, Hakenberg OW, et al. p16(INK4a) is a marker of good prognosis for primary invasive penile squamous cell carcinoma: a multi-institutional study. J Urol ;
21. Chahoud J, Zacharias NM, Pham R, et al. Prognostic Significance of p16 and Its Relationship with Human Papillomavirus Status in Patients with Penile Squamous Cell Carcinoma: Results of 5 Years Follow-Up. Cancers (Basel) ;
22. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM. Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet ;
23. Dillner J, von Krogh G, Horenblas S, Meijer CJ. Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl ;
24. Harish K, Ravi R. The role of tobacco in penile carcinoma. Br J Urol ;
25. Holly EA, Palefsky JM. Factors related to risk of penile cancer: new evidence from a study in the Pacific Northwest. J Natl Cancer Inst ;
26. Stern RS. Genital tumors among men with psoriasis exposed to psoralens and ultraviolet A radiation (PUVA) and ultraviolet B radiation. The Photochemotherapy Follow-up Study. N Engl J Med ;
27. Hunter JS, Saslawsky M. Penile mass in a year-old patient. Obstruction of smegma-producing glands. Am Fam Physician ;
28. Van Howe RS, Hodges FM. The carcinogenicity of smegma: debunking a myth. J Eur Acad Dermatol Venereol ;
29. Thomas A, Necchi A, Muneer A, et al. Penile cancer. Nat Rev Dis Primers ;
30. Depasquale I, Park AJ, Bracka A. The treatment of balanitis xerotica obliterans. BJU Int ;
31. Micali G, Nasca MR, Innocenzi D. Lichen sclerosus of the glans is significantly associated with penile carcinoma. Sex Transm Infect ;
32. Velazquez EF, Cubilla AL. Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role. Am J Surg Pathol ;
33. Moch H, Amin MB, Berney DM, et al. The World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol ;
34. Kristiansen S, Svensson Å, Drevin L, et al. Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, Acta Derm Venereol ;
35. Hoekstra RJ, Trip EJ, Ten Kate FJ, et al. Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands. Int J Urol ;
36. Moch H, Cubilla AL, Humphrey PA, et al. The WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours. Eur Urol ;
37. Sanchez DF, Soares F, Alvarado-Cabrero I, et al. Pathological factors, behavior, and histological prognostic risk groups in subtypes of penile squamous cell carcinomas (SCC). Semin Diagn Pathol ;
38. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res ;
39. Guimarães GC, Lopes A, Campos RS, et al. Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases. Urology ;
40. da Cunha IW, Souza MJ, da Costa WH, et al. Epithelial-mesenchymal transition (EMT) phenotype at invasion front of squamous cell carcinoma of the penis influences oncological outcomes. Urol Oncol ; e
41. Minardi D, Lucarini G, Filosa A, et al. Prognostic value of CD44 expression in penile squamous cell carcinoma: a pilot study. Cell Oncol (Dordr) ;
42. Ferrandiz-Pulido C, Masferrer E, Toll A, et al. mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior. J Urol ;
43. Steinestel J, Al Ghazal A, Arndt A, et al. The role of histologic subtype, p16(INK4a) expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma. BMC Cancer ;
44. Yugawa T, Kiyono T. Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins. Rev Med Virol ;
45. Klingelhutz AJ, Foster SA, McDougall JK. Telomerase activation by the E6 gene product of human papillomavirus type Nature ;
46. Gewin L, Myers H, Kiyono T, Galloway DA. Identification of a novel telomerase repressor that interacts with the human papillomavirus type E6/E6-AP complex. Genes Dev ;
47. Chahoud J, Gleber-Netto FO, McCormick BZ, et al. Whole-exome Sequencing in Penile Squamous Cell Carcinoma Uncovers Novel Prognostic Categorization and Drug Targets Similar to Head and Neck Squamous Cell Carcinoma. Clin Cancer Res ;
48. de Vries HM, Ottenhof SR, Horenblas S, et al. Defining the Tumor Microenvironment of Penile Cancer by Means of the Cancer Immunogram. Eur Urol Focus ;
49. Blank CU, Haanen JB, Ribas A, Schumacher TN. CANCER IMMUNOLOGY. The "cancer immunogram". Science ;
50. Nagarsheth NB, Norberg SM, Sinkoe AL, et al. TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers. Nat Med ;
51. Udager AM, Liu TY, Skala SL, et al. Frequent PD-L1 expression in primary and metastatic penile squamous cell carcinoma: potential opportunities for immunotherapeutic approaches. Ann Oncol ;
52. Ottenhof SR, Djajadiningrat RS, de Jong J, et al. Expression of Programmed Death Ligand 1 in Penile Cancer is of Prognostic Value and Associated with HPV Status. J Urol ;
53. Deng C, Li Z, Guo S, et al. Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma. Oncoimmunology ; 6:e
54. Topalian SL, Hodi FS, Brahmer JR. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. New England Journal of Medicine ;
55. Fan YS, Carr RA, Sanders DS, et al. Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. Histopathology ;
56. Grossman HB. Premalignant and early carcinomas of the penis and scrotum. Urol Clin North Am ;
57. Pettaway CA, Lance RS, Davis JW. Tumors of the penis. In: Cambell-Walsh Urology, 10th ed, Kavoussi LR, Novick AC, Partin AW, et al (Eds), Saunders Elsevier, Philadelphia p
58. Jaffe HW, Bregman DJ, Selik RM. Acquired immune deficiency syndrome in the United States: the first 1, cases. J Infect Dis ;
59. Bayne D, Wise GJ. Kaposi sarcoma of penis and genitalia: a disease of our times. Urology ;
60. Dehner LP, Smith BH. Soft tissue tumors of the penis. A clinicopathologic study of 46 cases. Cancer ;
61. Moore SW, Wheeler JE, Hefter LG. Epitheloid sarcoma masquerading as Peyronie's disease. Cancer ;
62. ASHLEY DJ, EDWARDS EC. Sarcoma of the penis; leiomyosarcoma of the penis: report of a case with a review of the literature on sarcoma of the penis. Br J Surg ;
63. Parsons MA, Fox M. Malignant fibrous histiocytoma of the penis. Eur Urol ;
64. Rasbridge SA, Parry JR. Angiosarcoma of the penis. Br J Urol ;
65. Planz B, Brunner K, Kalem T, et al. Primary leiomyosarcoma of the epididymis and late recurrence on the penis. J Urol ;
66. Leviav A, Devine PC, Schellhammer PF, Horton CE. Epithelioid sarcoma of the penis. Clin Plast Surg ;
67. Kamat AM, Plager C, Tamboli P, et al. Metastatic epithelioid hemangioendothelioma of the penis managed with surgery and interferon-alpha. J Urol ;
68. Sacker AR, Oyama KK, Kessler S. Primary osteosarcoma of the penis. Am J Dermatopathol ;
69. Anolik R, Liang C, Wang N, et al. Extramammary Paget disease. Dermatol Online J ;
70. Kim SA, Kwon JI, Jung HR, et al. Primary Extramammary Paget's Disease Combined with Bowen's Disease in Vulva. Ann Dermatol ; S
71. Chaux A, Amin M, Cubilla AL, Young RH. Metastatic tumors to the penis: a report of 17 cases and review of the literature. Int J Surg Pathol ;
72. Powell BL, Craig JB, Muss HB. Secondary malignancies of the penis and epididymis: a case report and review of the literature. J Clin Oncol ;

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